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Batch queries can be done using pipe "|" as a separator between search terms. Note: Direct classification on the basis of the prior probability alone is a misuse of the Bayesian integrated evaluation model, therefore the dynamic range of the prior probability (Prior P) has been truncated to a minimum of 0.10 and a maximum of 0.90 so that additional sources of information are required to reach posterior probabilities that alter clinical management of patients with variants.
LOVD - Variant listings for MLH1_priors

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Exon Hide Exon column Descending
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DNA change   Descending
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RNA change Hide RNA change column Descending
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Protein Hide Protein column Descending
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MAPP score Hide MAPP score column Descending
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Custom PP2.1 score Hide Custom PP2.1 score column Descending
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MAPP/PP2 Prior P Hide MAPP/PP2 Prior P column Descending
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15 c.1686G>T - p.Q562H 14.36 0.981 0.7364 Thompson et al., 2013 DNA SEQ MLH1_03701
15 c.1687A>C - p.I563L 3.9 0.02 0.0024 Thompson et al., 2013 DNA SEQ MLH1_03702
15 c.1687A>G - p.I563V 10.09 0.239 0.0505 Thompson et al., 2013 DNA SEQ MLH1_03703
15 c.1687A>T - p.I563L 3.9 0.02 0.0024 Thompson et al., 2013 DNA SEQ MLH1_03704
15 c.1688T>A - p.I563K 28.52 0.451 0.5811 Thompson et al., 2013 DNA SEQ MLH1_03705
15 c.1688T>C - p.I563T 21.84 0.357 0.3365 Thompson et al., 2013 DNA SEQ MLH1_03706
15 c.1688T>G - p.I563R 34.19 0.112 0.3306 Thompson et al., 2013 DNA SEQ MLH1_03707
15 c.1689A>G - p.I563M 11.12 0.673 0.2963 Thompson et al., 2013 DNA SEQ MLH1_03708
15 c.1690C>A - p.L564I 2.48 0.052 0.001 Thompson et al., 2013 DNA SEQ MLH1_03709
15 c.1690C>G - p.L564V 5.04 0.141 0.0072 Thompson et al., 2013 DNA SEQ MLH1_03710
15 c.1690C>T - p.L564F 3.61 0.045 0.0023 Thompson et al., 2013 DNA SEQ MLH1_03711
15 c.1691T>A - p.L564H 13.42 0.776 0.5001 Thompson et al., 2013 DNA SEQ MLH1_03712
15 c.1691T>C - p.L564P 13.24 0.725 0.4384 Thompson et al., 2013 DNA SEQ MLH1_03713
15 c.1691T>G - p.L564R 34.43 0.817 0.91 Thompson et al., 2013 DNA SEQ MLH1_03714
15 c.1693A>C - p.I565L 2.21 0.001 0.0006 Thompson et al., 2013 DNA SEQ MLH1_03715
15 c.1693A>G - p.I565V 10.13 0.001 0.0191 Thompson et al., 2013 DNA SEQ MLH1_03716
15 c.1693A>T - p.I565F 7.91 0.121 0.0182 Thompson et al., 2013 DNA SEQ MLH1_03717
15 c.1694T>A - p.I565N 22.85 0.239 0.2537 Thompson et al., 2013 DNA SEQ MLH1_03718
15 c.1694T>C - p.I565T 18.23 0.029 0.0768 Thompson et al., 2013 DNA SEQ MLH1_03719
15 c.1694T>G - p.I565S 22.76 0.121 0.1693 Thompson et al., 2013 DNA SEQ MLH1_03720
15 c.1695T>G - p.I565M 6.97 0.011 0.0086 Thompson et al., 2013 DNA SEQ MLH1_03721
15 c.1696T>A - p.Y566N 3.63 0.616 0.0254 Thompson et al., 2013 DNA SEQ MLH1_03722
15 c.1696T>C - p.Y566H 11.89 0.679 0.3346 Thompson et al., 2013 DNA SEQ MLH1_03723
15 c.1696T>G - p.Y566D 24.37 0.413 0.4522 Thompson et al., 2013 DNA SEQ MLH1_03724
15 c.1697A>C - p.Y566S 3.57 0.413 0.0104 Thompson et al., 2013 DNA SEQ MLH1_03725
15 c.1697A>G - p.Y566C 3.75 0.028 0.0023 Thompson et al., 2013 DNA SEQ MLH1_03726
15 c.1697A>T - p.Y566F 2.23 0.016 0.0007 Thompson et al., 2013 DNA SEQ MLH1_03727
15 c.1699G>A - p.D567N 5.19 0.276 0.0136 Thompson et al., 2013 DNA SEQ MLH1_03728
15 c.1699G>C - p.D567H 7.67 0.932 0.3532 Thompson et al., 2013 DNA SEQ MLH1_03729
15 c.1699G>T - p.D567Y 9.15 0.958 0.4766 Thompson et al., 2013 DNA SEQ MLH1_03730
15 c.1700A>C - p.D567A 20.29 0.875 0.7958 Thompson et al., 2013 DNA SEQ MLH1_03731
15 c.1700A>G - p.D567G 11.06 0.713 0.3303 Thompson et al., 2013 DNA SEQ MLH1_03732
15 c.1700A>T - p.D567V 28.33 0.912 0.9069 Thompson et al., 2013 DNA SEQ MLH1_03733
15 c.1701T>A - p.D567E 8.55 0.178 0.0274 Thompson et al., 2013 DNA SEQ MLH1_03734
15 c.1701T>G - p.D567E 8.55 0.178 0.0274 Thompson et al., 2013 DNA SEQ MLH1_03735
15 c.1702T>A - p.F568I 10.86 0.995 0.6113 Thompson et al., 2013 DNA SEQ MLH1_03736
15 c.1702T>C - p.F568L 12.82 0.986 0.6881 Thompson et al., 2013 DNA SEQ MLH1_03737
15 c.1702T>G - p.F568V 17.61 0.995 0.8249 Thompson et al., 2013 DNA SEQ MLH1_03738
15 c.1703T>A - p.F568Y 16.28 0.993 0.7963 Thompson et al., 2013 DNA SEQ MLH1_03739
15 c.1703T>C - p.F568S 19.43 0.995 0.8549 Thompson et al., 2013 DNA SEQ MLH1_03740
15 c.1703T>G - p.F568C 17.91 0.999 0.8328 Thompson et al., 2013 DNA SEQ MLH1_03741
15 c.1704T>A - p.F568L 12.82 0.986 0.6881 Thompson et al., 2013 DNA SEQ MLH1_03742
15 c.1704T>G - p.F568L 12.82 0.986 0.6881 Thompson et al., 2013 DNA SEQ MLH1_03743
15 c.1705G>A - p.A569T 18.98 0.33 0.2474 Thompson et al., 2013 DNA SEQ MLH1_03744
15 c.1705G>C - p.A569P 19.66 0.603 0.5325 Thompson et al., 2013 DNA SEQ MLH1_03745
15 c.1705G>T - p.A569S 7.53 0.167 0.0197 Thompson et al., 2013 DNA SEQ MLH1_03746
15 c.1706C>A - p.A569D 41.16 0.352 0.6766 Thompson et al., 2013 DNA SEQ MLH1_03747
15 c.1706C>G - p.A569G 1.24 0.001 0.0002 Thompson et al., 2013 DNA SEQ MLH1_03748
15 c.1706C>T - p.A569V 28.27 0.33 0.4481 Thompson et al., 2013 DNA SEQ MLH1_03749
15 c.1708A>C - p.N570H 9.67 0.981 0.5324 Thompson et al., 2013 DNA SEQ MLH1_03750
15 c.1708A>G - p.N570D 5.95 0.292 0.0197 Thompson et al., 2013 DNA SEQ MLH1_03751
15 c.1708A>T - p.N570Y 18.97 0.981 0.8402 Thompson et al., 2013 DNA SEQ MLH1_03752
15 c.1709A>C - p.N570T 13.62 0.943 0.6782 Thompson et al., 2013 DNA SEQ MLH1_03753
15 c.1709A>G - p.N570S 11.61 0.901 0.5508 Thompson et al., 2013 DNA SEQ MLH1_03754
15 c.1709A>T - p.N570I 30 0.981 0.937 Thompson et al., 2013 DNA SEQ MLH1_03755
15 c.1710T>A - p.N570K 11.96 0.909 0.5758 Thompson et al., 2013 DNA SEQ MLH1_03756
15 c.1710T>G - p.N570K 11.96 0.909 0.5758 Thompson et al., 2013 DNA SEQ MLH1_03757
15 c.1711T>A - p.F571I 10.86 0.883 0.4939 Thompson et al., 2013 DNA SEQ MLH1_03758
15 c.1711T>C - p.F571L 12.82 0.805 0.505 Thompson et al., 2013 DNA SEQ MLH1_03759
15 c.1711T>G - p.F571V 17.61 0.82 0.691 Thompson et al., 2013 DNA SEQ MLH1_03760
15 c.1712T>A - p.F571Y 16.28 0.096 0.0789 Thompson et al., 2013 DNA SEQ MLH1_03761
15 c.1712T>C - p.F571S 19.43 0.912 0.8053 Thompson et al., 2013 DNA SEQ MLH1_03762
15 c.1712T>G - p.F571C 17.91 0.157 0.1212 Thompson et al., 2013 DNA SEQ MLH1_03763
15 c.1713T>A - p.F571L 12.82 0.805 0.505 Thompson et al., 2013 DNA SEQ MLH1_03764
15 c.1713T>G - p.F571L 12.82 0.805 0.505 Thompson et al., 2013 DNA SEQ MLH1_03765
15 c.1714G>A - p.G572S 7.21 0.292 0.0301 Thompson et al., 2013 DNA SEQ MLH1_03766
15 c.1714G>C - p.G572R 45.32 0.958 0.9718 Thompson et al., 2013 DNA SEQ MLH1_03767
15 c.1714G>T - p.G572C 18.6 0.981 0.8341 Thompson et al., 2013 DNA SEQ MLH1_03768
15 c.1715G>A - p.G572D 41.61 0.909 0.9583 Thompson et al., 2013 DNA SEQ MLH1_03769
15 c.1715G>C - p.G572A 5.73 0.447 0.0345 Thompson et al., 2013 DNA SEQ MLH1_03770
15 c.1715G>T - p.G572V 27.3 0.932 0.907 Thompson et al., 2013 DNA SEQ MLH1_03771
15 c.1717G>A - p.V573I 1.37 0.005 0.0002 Thompson et al., 2013 DNA SEQ MLH1_03772
15 c.1717G>C - p.V573L 4.27 0.009 0.0028 Thompson et al., 2013 DNA SEQ MLH1_03773
15 c.1717G>T - p.V573F 4.77 0.009 0.0036 Thompson et al., 2013 DNA SEQ MLH1_03774
15 c.1718T>A - p.V573D 36.23 0.272 0.5269 Thompson et al., 2013 DNA SEQ MLH1_03775
15 c.1718T>C - p.V573A 7.38 0.029 0.0106 Thompson et al., 2013 DNA SEQ MLH1_03776
15 c.1718T>G - p.V573G 7.92 0.253 0.0315 Thompson et al., 2013 DNA SEQ MLH1_03777
15 c.1720C>A - p.L574I 8.65 0.015 0.0142 Thompson et al., 2013 DNA SEQ MLH1_03778
15 c.1720C>G - p.L574V 14.4 0.071 0.055 Thompson et al., 2013 DNA SEQ MLH1_03779
15 c.1720C>T - p.L574F 5.97 0.013 0.0061 Thompson et al., 2013 DNA SEQ MLH1_03780
15 c.1721T>A - p.L574H 14.74 0.619 0.3881 Thompson et al., 2013 DNA SEQ MLH1_03781
15 c.1721T>C - p.L574P 20.37 0.553 0.4994 Thompson et al., 2013 DNA SEQ MLH1_03782
15 c.1721T>G - p.L574R 35.81 0.676 0.8584 Thompson et al., 2013 DNA SEQ MLH1_03783
15 c.1723A>G - p.R575G 23.76 0.305 0.3297 Thompson et al., 2013 DNA SEQ MLH1_03784
15 c.1723A>T - p.R575W 19.39 0.719 0.644 Thompson et al., 2013 DNA SEQ MLH1_03785
15 c.1724G>A - p.R575K 3.47 0.005 0.0017 Thompson et al., 2013 DNA SEQ MLH1_03786
15 c.1724G>C - p.R575T 22.59 0.121 0.1669 Thompson et al., 2013 DNA SEQ MLH1_03787
15 c.1724G>T - p.R575M 14.54 0.528 0.2944 Thompson et al., 2013 DNA SEQ MLH1_03788
15 c.1725G>C - p.R575S 19.67 0.016 0.0855 Thompson et al., 2013 DNA SEQ MLH1_03789
15 c.1725G>T - p.R575S 19.67 0.016 0.0855 Thompson et al., 2013 DNA SEQ MLH1_03790
15 c.1726T>A - p.L576I 15.46 0.846 0.6502 Thompson et al., 2013 DNA SEQ MLH1_03791
15 c.1726T>G - p.L576V 25.8 0.292 0.3595 Thompson et al., 2013 DNA SEQ MLH1_03792
15 c.1727T>C - p.L576S 22.76 0.932 0.8658 Thompson et al., 2013 DNA SEQ MLH1_03793
15 c.1728A>C - p.L576F 12.59 0.292 0.0992 Thompson et al., 2013 DNA SEQ MLH1_03794
15 c.1728A>T - p.L576F 12.59 0.292 0.0992 Thompson et al., 2013 DNA SEQ MLH1_03795
15 c.1729T>A - p.S577T 3.7 0.025 0.0022 Thompson et al., 2013 DNA SEQ MLH1_03796
15 c.1729T>C - p.S577P 31.05 0.011 0.2052 Thompson et al., 2013 DNA SEQ MLH1_03797
15 c.1729T>G - p.S577A 24.49 0.18 0.2363 Thompson et al., 2013 DNA SEQ MLH1_03798
15 c.1730C>G - p.S577W 16.4 0.945 0.7641 Thompson et al., 2013 DNA SEQ MLH1_03799
15 c.1730C>T - p.S577L 31.78 0.364 0.5504 Thompson et al., 2013 DNA SEQ MLH1_03800
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Note: Direct classification on the basis of the prior probability alone is a misuse of the Bayesian integrated evaluation model, therefore the dynamic range of the prior probability (Prior P) has been truncated to a minimum of 0.10 and a maximum of 0.90 so that additional sources of information are required to reach posterior probabilities that alter clinical management of patients with variants.

Legend: [ MLH1_priors full legend ]
Sequence variations are described basically as recommended by the Ad-Hoc Committee for Mutation Nomenclature (AHCMN), with the recently suggested additions (den Dunnen JT and Antonarakis SE [2000], Hum.Mut. 15:7-12); for a summary see Nomenclature.
Exon: Exon numbering. DNA change: Variation at DNA-level. If present, "Full Details" will show you the the full-length entry. RNA change: Variation at RNA-level, (?) unknown but probably identical to DNA. Protein: Variation at protein level. MAPP score: output score from MAPP Custom PP2.1 score: Custom PolyPhen 2.1 score MAPP/PP2 Prior P: MAPP/PP2 Prior probability of pathogenicity Reference: Reference describing the variation, "Submitted:" indicating that the mutation was submitted directly to this database. Template: Variant detected in DNA, RNA and/or Protein. Technique: Technique used to detect the variation. MLH1 DB-ID: Database IDentifier; When available, links to OMIM ID's are provided.

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